In 2005, an article was published in Virology Journal titled “Chloroquine is a potent inhibitor of SARS coronavirus infection and spread. The eight authors were associated with the Centers for Disease Control and Montreal’s Clinical Research Institute. The study described in the article was conducted in the wake of the SARS epidemic:
Severe acute respiratory syndrome (SARS) is caused by a newly discovered coronavirus (SARS-CoV). No effective prophylactic or post-exposure therapy is currently available.
We report, however, that chloroquine has strong antiviral effects on SARS-CoV infection of primate cells. These inhibitory effects are observed when the cells are treated with the drug either before or after exposure to the virus, suggesting both prophylactic and therapeutic advantage. In addition to the well-known functions of chloroquine such as elevations of endosomal pH, the drug appears to interfere with terminal glycosylation of the cellular receptor, angiotensin-converting enzyme 2. This may negatively influence the virus-receptor binding and abrogate the infection, with further ramifications by the elevation of vesicular pH, resulting in the inhibition of infection and spread of SARS CoV at clinically admissible concentrations.
It's amazing how this drug has become such a political issue. How is it that a drug that has shown promising evidence in not one, but two coronavirus applications is still seen as a partisan issue? Is Trump correct in saying that if he told people "not" to use it, that Democrats would have fallen in line and demanded everyone take it? Is he also correct to say that his personal endorsement of the drug has led certain people to not support it's use?
7 comments:
This was why it was one of the first things off the shelf that was tried.
To here Democrats and the media tell it, hydroxicholorquine is some dangerous new untried drug.
That is not the case. It's been around for over 50 years with an exemplary safety and effectiveness record.
Lil Schitty is now an expert in experimental medicine......BWAAAAAAAAA!!!!!1 Yeah that's why they are going to finish their trials and answer the question....as for cramps....hydroxcloroquine can kill you just as easy as helping you!!!!!! If it can help!!!!! BWAAAAAAAAAAA!!!!
.hydroxcloroquine can kill you just as easy as helping you!!!!!! If it can help!!!!!
This is demonstrably false. Hydroxchloroquine has been use to treat Malaria and Lupus patients for years with almost no adverse effects. It's about as safe as aspirin.
Earth to Dr Cramps......once again your opinion is not supported by facts......god you are dumber than the loser from Ga!!!!!
https://www.nytimes.com/2020/04/05/us/politics/trump-hydroxychloroquine-coronavirus.html
BTW...aspirin can kill you just like hydroxy can you dumb fuck!!!!!
For the massively stupid Dr. Cramps....
own coronavirus task force. And while many hospitals have chosen to use hydroxychloroquine in a desperate attempt to treat dying patients who have few other options, others have noted that it carries serious risks. In particular, the drug can cause a heart arrhythmia that can lead to cardiac arrest.
"Physicians and patients should be aware of several rare but potentially life-threatening adverse effects of chloroquine and hydroxychloroquine," said study researcher Dr David Juurlink, Division of Clinical Pharmacology and Toxicology, Sunnybrook Health Sciences Centre in Canada.
The review provides an overview of potential harms associated with these drugs as well as their management based on the best available evidence.
According to the study, potential adverse effects include cardiac arrhythmias-- Improper beating of the heart, whether irregular, too fast or too slow, Hypoglycemia-- It is a condition in which your blood sugar (glucose) level is lower than normal and overdose (chloroquine and hydroxychloroquine are highly toxic in overdose and can cause seizures, coma and cardiac arrest)Neuropsychiatric effects, such as agitation, confusion, hallucinations and paranoia.
Interactions with other drugs, Metabolic variability (some people metabolize chloroquine and hydroxychloroquine poorly and a small percentage metabolize them rapidly, which affects the response to treatment).
Drug shortages (patients with autoimmune disorders such as rheumatoid arthritis, lupus and other chronic diseases, who take hydroxychloroquine to treat these conditions could have problems accessing this drug).
The review summarizes the poor quality of evidence suggesting that these treatments might be beneficial in patients with COVID-19 and cautions that it is possible that these treatments could worsen the disease.
"Despite optimism (in some, even enthusiasm) for the potential of chloroquine or hydroxychloroquine in the treatment of COVID-19, little consideration has been given to the possibility that the drugs might negatively influence the course of disease," said Dr Juurlink.
"This is why we need a better evidence base before routinely using these drugs to treat patients with COVID-19," Juurlink added.
Fact: Not only is Hydroxychloroquine used to treat malaria is also used as a prophylactic prescribed to travelers to malaria infested regions.
Fact: Lupus patients take it long-term for treatment of their symptoms.
Like much of the New York Times reporting nowadays, this story is crap.
Just a question, how many people have you known who has died of an aspirin overdose?
I don't know anybody.
Then again I also don't know anybody stupid enough to ingest fish tank cleaner.
I suspect you do. And they are probably related to you.
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